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The trial, conducted across multiple international sites and involving 725 adults living with obesity or overweight but without type 2 diabetes, concluded in April 2026 after 76 weeks of treatment

267(11) 7402 | DOI : PMID: 1313797 J

Initial improvements become visible within two to four weeks as acute swelling subsides

Gary further noted that adipose tissue is metabolically active and can affect estrogen production and inflammatory signaling, both of which are involved in breast cancer biology

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