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Researchers said weight regain has been reported after stopping other obesity medications, and overall data confirm the chronicity of obesity and highlight the importance of maintaining long-term pharmacological treatment for weight management in people with obesity. The success of GLP-1 medications can depend on how long people use them

Frossing S, Nylander M, Kistorp C, Skouby SO, Faber J (2018) Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS

One interesting possibility is that differences in prolonged dietary exposure, including chronic exposure to high-fat diets, leads to structural and functional changes in the gut nutrient-sensing pathways (48)

Look, M., Dunn, J

Liraglutide, a GLP-1 receptor agonist, improves weight and glycaemic control in patients with T2DM