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Polymorphisms in genes such as ABCG8 and ABCG5, which encode transporters involved in the flow of cholesterol into the bile, have been linked to an increased risk of gallstone formation

T3 can also centrally modulate hepatic glucose production and insulin sensitivity by acting on the sympathetic pathway, connecting the paraventricular hypothalamus to the liver (141)

Ganoderma applanatum polysaccharides significantly reduced total cholesterol, triglycerides, low-density lipoprotein cholesterol levels and atherosclerotic index in obese rats, improving the symptoms of dyslipidemia [134]

This is a great piece of the jigsaw PhD biochemist here

They mimic a natural hormone which helps regulate appetite, blood sugar, and insulin levels