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One study found that 27% of women and 19% of men on very low-calorie diets reported decreased libido, and men on an eight-week, 1,200-calorie diet experienced a 30% reduction in total testosterone levels

These medications carry a boxed warning regarding thyroid C-cell tumor risk observed in rodent studies and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Kushner is excited about signals that these drugs may reduce addiction across substances, from alcohol to nicotine, and about possible roles in cognitive and other conditions, though those will be much harder to study

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