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The SELECT trial demonstrated that semaglutide 2.4 mg reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) by 20% in adults with overweight or obesity and established heart disease (Lincoff et al., SELECT trial, New England Journal of Medicine , 2023)

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However, no trial specifically studied the effects of routinely shortened intervals

The medication primarily targets metabolic pathways through GIP and GLP-1 receptors, which are widely expressed in pancreatic tissue, the gastrointestinal tract, adipose tissue, and certain brain regions involved in appetite regulation