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Recently, using an untargeted integrative genomics approach, a set of genes that contained variants associated with GLP-1-stimulated insulin secretion were described, which at the same time have the potential to physically interact in the -cell and are enriched for pathways that are important for insulin secretion [570]

Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell

First, FAERS spontaneous reporting architecture introduces selection biases in ethnicity, geographic representation, and temporal reporting patterns tied to drug approval timelines and public awareness cycles 18

Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia

That is a 30-percentage-point reduction in insulin resistance prevalence