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Following reports of self-injury and suicidal thoughts among a small number of people whove taken Ozempic or Wegovy in Europe and the United Kingdom, health regulators there are investigating whether the drugs carry a risk of these side effects

Every number below assumes accurate reconstitution, so measure your bacteriostatic water carefully using a reconstitution calculator before your first draw

However, for people with high insulin resistance or PCOS, the weight loss can be more significant because the medication addresses the underlying metabolic root cause of their weight gain

The Headline Figures In the 48-week trial, participants receiving the highest dose of retatrutide (12 mg) lost an average of 24.2% of their body weight

While metformin has long served as the standard first-line therapy, many clinicians are now reconsidering whether a metformin-first and wait strategy is enough for this higher-risk population