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GLP-1 agonists may be preferable in some elderly patients due to lower hypoglycemia risk, though GI side effects and potential for weight loss (which can be undesirable in frail elderly patients) require careful consideration

However, when paired with GLP-1 in dual agonists like tirzepatide, the combination works synergistically to suppress appetite and increase energy expenditure

Maintaining adequate hydration is important

Mood and Emotional Eating : By improving mood and reducing emotional eating, saffron may indirectly mimic one of the effects of GLP-1 receptor agonists, which also reduce reward-based eating behavior

This was followed by an assessment of the cost-effectiveness of using GLP-1 RAs