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Pre-existing neuropathy The case of the 75-year-old man with baseline neuropathy who developed severe allodynia on tirzepatide suggests that pre-existing nerve damage may create vulnerability

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This finding is particularly significant as it demonstrates that the cardiovascular benefits of GLP-1 agonists extend beyond their glucose-lowering effects to encompass direct cardiovascular protection in obesity

doi: 10.1111/ijcp.13731