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[6] The only notable exception is that biotin should not be used in anyone with a known hypersensitivity or allergy to biotin or any ingredients in the injection formulation (such as the diluent or preservatives), though such cases are exceedingly rare

This is the only meta-analysis to date conducted on this topic, although the authors say their results should be interpreted with caution due to the observational design of the studies included in the review

The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications