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For example, semaglutide typically starts at a low dose (0.25 mg weekly) and increases to a maintenance dose (2.4 mg weekly for weight loss) over 16 to 20 weeks
Starting at low doses and slowly increasing over weeks to months significantly improves tolerability
2021;11:e2231
In the intestine and to a lesser extent in the pancreatic -cells, the processing of the proglucagon results in the formation of at least three GLP-1 peptides of 37, 31, and 30 residues [36]
