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When we think about oral formulations of novel weight management products, we need to keep in mind that they are absorbed from the small intestine, enter the portal vein, and are transported to the liver, which mimics physiological pathways of endogenous incretins sectered by various enteroencrine cells

however, dialysis patients were not included within the scope of the study

Liraglutide is equipotent to GLP-1 in activating GLP-1R, with an EC50 of 61 pM for liraglutide vs

Diabetes Obes Metab (2014) 16(9):85060
They found that GLP-1 users had a 45% reduced risk of developing dementia compared to those who didnt take these medications
