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Glycemic effects remain relevant, particularly in patients with prediabetes or insulin resistance, but they are no longer the defining measure of success

Lancet 2022;400

On balance, the data and arguments presented above suggest some separation between those receptors accessible to gutderived hormonal GLP1 and brainderived neuromodulatory GLP1, but fail to deliver unequivocal proof
They are all older Caucasian females

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