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Despite variations in data sources, adjustment techniques, risk estimates, and comparator drugs, these findings collectively suggest that GLP-1RAs are not associated with an altered risk of depression

Mazdutide , a dual GLP-1/glucagon agonist, is in development and shows promising results in early trials, particularly in Asian populations

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The primary mechanism of action involves binding to GLP-1 receptors located throughout the body, including the pancreas, brain, and gastrointestinal tract

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