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Thomas MK et al (2021) Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes

Activating GIP receptors appears to promote bone formation and inhibit bone resorption, at least in preclinical studies

But each additional crumple makes it less recognizable, less functional, less capable of doing what it was designed to do

The cost of retatrutide through research suppliers currently runs higher per milligram than compounded tirzepatide, largely because of limited manufacturing scale and the absence of compounding pharmacy competition

Tirzepatide may improve glycemic control by directly and indirectly affecting the pancreas and other tissues