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If the package feels warm or has been in transit for extended periods without adequate cooling, patients should contact their pharmacy to verify whether the medication remains safe to use

This is consistent with general tirzepatide weight loss timelines , which typically show 5 to 10 percent body weight reduction within the first three to six months, with continued loss for those who titrate to higher doses

Most are mild, often linked to how the medication affects your stomach and appetite, and improve over time, particularly after the early weeks of treatment or dose increases

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Why Medicare Does Not Cover Weight Loss Drugs The restriction dates back to older Medicare policy that excludes drugs used for weight loss, even as newer GLP-1 medications have shown benefits for: Obesity