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Canadian Journal of Gastroenterology and Hepatology, 2021 (1), 8936865
Cardiovascular Safety : The cardiovascular safety of tirzepatide has been evaluated and confirmed to date through a pre-specified meta-analysis of phase 2 and 3 randomized trials comparing tirzepatide with other placebo, insulin glargine, degludec, semaglutide, dulaglutide for a minimum of 26 weeks (including the GPGB, SURPASS 1,2,3,4,5, and J-mono studies) [67]
2024;385:p

Accelerometer measurements supported these findings, with MVPA of 134 minutes/day in the exercise group and 105 minutes/day in the combination group, versus 95 minutes/day for placebo and 88 minutes/day for liraglutide alone [15]
