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Dulaglutide, a long-acting GLP-1 analog fused with an Fc fragment

Known under brand names like Wegovy for weight loss and Ozempic for type 2 diabetes, semaglutide has shown effectiveness in helping patients reduce their body weight by 15 to 20 percent when combined with lifestyle changes

Methods Peptide synthesis All peptides were prepared using ChemMatrix Rink amide resin and Fmoc-based automated peptide synthesis on a Prelude X peptide synthesizer (Gyros Protein Technologies) with induction heating and oscillation mixing

298.Mann DM, Ponieman D, Montori VM, Arciniega J, McGinn T