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These trials are critical because they provide the final data needed for regulatory review. MNT spoke with Jeffrey Kraft, MD, chief of general surgery, specializing in bariatric surgery, for Palisades Medical Center in New Jersey, about this study, who commented that his initial reaction to the results was one of measured optimism

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Tirzepatide may be an effective option for adults struggling with obesity or excess weight, especially if traditional approaches havent achieved the desired results

For example, the follow-up period may have been insufficient to detect a difference between intervention and control arms, the trial may have failed to reach adequate therapeutic doses in affected regions of the central nervous system (Boxer and Sperling, 2023), or population heterogeneity may not have been adequately accounted for in the selection of the study population