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These numbers mean that if you are reading this article because a nodule showed up on a scan, you are in the majority, not the minority

Approximately 15-20% of patients experience diminished response or resistance to GLP-1 therapy, a phenomenon rooted in individual genetic variation and metabolic adaptation

doi: 10.1111/j.1463-1326.2012.01567.x
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Keeping a record of your past efforts can help support your case