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M.et al (2016)

According to Truveta Research presented at ISPOR 2025, side effects were the leading reason patients stopped taking GLP-1 medications, accounting for 28.2% of all discontinuations

Retatrutide: not yet available through standard channels Retatrutide is not FDA-approved

An increase in PKA activity also causes ATP-sensitive potassium channels to close, thereby depolarizing the cell membrane and opening voltage-gated calcium channels

Patients should undergo TSH and free thyroid hormone testing every 68 weeks during the first months of semaglutide therapy, then every 3 months as treatment stabilizes, to detect any shifts requiring antithyroid or replacement hormone adjustment