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Semaglutide reduced major adverse cardiovascular events in patients with type 2 diabetes at high cardiovascular risk. (Marso, New England Journal of Medicine )

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Estimands and robustness assessment Two estimands were used to assess the robustness of the results: Hypothetical strategy: Included data from all randomized participants until initiation or change in symptomatic therapy Treatment policy strategy: Included all data regardless of changes in symptomatic therapy