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The starting dose is designed for tolerability, not maximum efficacy
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In the Yin et al
Liu X, Kim JH, Wang J, Chen X, Zhang H, Kim SH, Cui J, Ruidong L, Zhang W, Kong Y, Zhang J, Shui W, Lamplot J, Rogers MR, Zhao C, Wang N, Tomal J, Statz J, Wang N, Rajan P (2013b) Wnt signaling in bone formation and its therapeutic potential for bone diseases
A landmark randomized controlled trial published in Cell in 2022 (Suez et al.) tested four sweeteners on 120 healthy adults
