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Some patients benefit from combination therapy with both classes

A crossover trial showed that meals containing olive oil (monounsaturated fat) produced meaningfully higher GLP-1 responses than equivalent meals with butter (saturated fat), particularly monounsaturated fatty acids (MUFAs) from olive oil (14g MUFA per tablespoon), avocado (10g MUFA per half), and nuts (almonds: 9g MUFA per ounce), are more effective at triggering GLP-1 release than saturated fats

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