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In general, oral diabetes medicines such as metformin are tried first for blood sugar control before injectables such as Ozempic are considered

[117] demonstrated that dapagliflozin provides direct cardiac protection by suppressing the NHE1/mitogen-activated protein kinase/activator protein-1 pathway-mediated inflammatory response in cardiomyocytes, reducing proinflammatory macrophage infiltration in the cardiac tissue of HF mice

N Engl J Med 2017;377:1327.ArticlePubMedPMC 4

[DOI] [PubMed] [Google Scholar] 56.Tchero H, Kangambega P, Briatte C, Brunet-Houdard S, Retali G-R, Rusch E