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Obes Pillars

In addition, evidence suggests that GLP-1 RAs may increase pancreatic enzyme secretion, while the expression and subsequent stimulation of GLP-1 receptors in pancreatic islet and exocrine duct cells have been correlated with overgrowth of the ductal epithelial cells, resulting in hyperplasia and chronic low-grade or acute inflammation, potentially leading to pancreatitis [89]

Indeed, it has been recognized that inappropriate activation of intrarenal RAS prevents the kidney from keeping normal Na + balance at normal renal perfusion pressures together with promoting glomerular, tubular and interstitial inflammation and fibrosis

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After four weeks, the dosage is generally increased to 0.5 mg per week