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Landmark clinical trials, such as the STEP programme for semaglutide published in The New England Journal of Medicine, have demonstrated that these medications can lead to average weight loss of 15% or more when combined with lifestyle changes, a level of efficacy previously achievable only through bariatric surgery

Studies reporting metabolic outcomes were the most common

GLP-1s take a two-pronged approach to managing diabetes or accelerating weight loss: Semaglutide affects your brains relationship with food as a reward, and Delays gastric emptying, slowing the rate at which you process meals As such, the majority of issues folks experience with semaglutide are stomach-related

24 May 2026

This coordinated response results in improved glucose homeostasis and sustained metabolic benefits