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Strategies to increase half-life To design GLP-RAs with an increased circulation time, a broad array of half-life extension strategies has been utilized including sequential modification (Byetta and Adlyxin), attachment of a fatty-acid (Victoza and Ozempic), development of a polymer-based sustained release formulation (Bydureon), fusion with human serum albumin (Tanzeum), and fusion with the fragment crystallizable (Fc) region of a monoclonal antibody (Trulicity) (Figure 1)

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