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Changes in the ratio of cortical R2* and medullary R2* also did not vary significantly between SGLT2 inhibitor users and nonusers in both semaglutide and placebo groups ( P -interaction=0.88 and P -interaction=0.84, respectively)

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Activation of the GLP-1R mediates neuroprotective effects through multiple mechanisms, including reducing neuroinflammation and oxidative stress, modulating synaptic plasticity, improving cognitive function and inhibiting neuronal apoptosis

Given their location and directionality of transport, they have the potential to translocate drug back into the gut lumen and reduce drug absorption