glp-1 agonist mechanism of action of [25] Evolution of GLP‐1 Receptor Agonists
Description
Absolute body weight reductions measured 10.2, 12.9, and 13.1 kg across the 2.4, 4.8, and 6 mg cohorts respectively vs
![glp-1 agonist mechanism of action of [25] Evolution of GLP1 Receptor Agonists](https://www.biochempeg.com/usr/uploads/3/202209/Biological-actions-of%20-GLP-1.png)
(Yes, liraglutide is also known as Victoza, but thats the formulation approved for diabetes management rather than weight loss Very much like the Ozempic and Wegovy story.) Saxenda, like a successful spin-off of a popular TV series, has been making waves since its FDA approval in 2014 for chronic weight management in adults with obesity or overweight and at least one weight-related comorbidity
![glp-1 agonist mechanism of action of [25] Evolution of GLP1 Receptor Agonists](https://www.frontiersin.org/files/Articles/1085799/xml-images/fendo-14-1085799-g001.webp)
Myosteatotic and sarcopenic obesity impact postoperative outcomes more robustly than visceral obesity in general surgery patients, with differences by sex
![glp-1 agonist mechanism of action of [25] Evolution of GLP1 Receptor Agonists](https://www.mdpi.com/nutrients/nutrients-18-01688/article_deploy/html/images/nutrients-18-01688-g001-550.jpg)
instead, shedding is more likely related to rapid weight loss and telogen effluvium
![glp-1 agonist mechanism of action of [25] Evolution of GLP1 Receptor Agonists](https://s3.amazonaws.com/production.scholastica/public/attachments/9c499677-aa6b-4e1e-9360-4d7e41721fd8/large/figure_1._mechanism_of_synthesis_of_glp-1.png)
Future studies will examine the optimal fasting duration for patients on GLP-1 agonists to establish consensus guidelines
![glp-1 agonist mechanism of action of [25] Evolution of GLP1 Receptor Agonists](https://pennmedicalgroup.com/wp-content/uploads/2023/09/glp-1-agonists.jpg)