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Most patients find that gastrointestinal symptoms diminish over time as the body adjusts to the medication, usually within 48 weeks

This can elevate the bile cholesterol saturation index, consequently promoting the formation of cholesterol stones, affecting gallbladder function, and disrupting bile acid metabolism ( We further explored potential mechanistic differences among various GLP-1 RAs in their associations with cholecystitis and cholelithiasis

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In particular, mortality rate was reduced in the GLP-1RAs group compared with the second- or third-line medications

Many mood-related symptoms during GLP-1 therapy are temporary and manageable