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These medications stimulate insulin release independent of glucose levels, and when combined with Zepbound's glucose-lowering effects, can precipitate hypoglycemic episodes

Glucagon Suppression It inhibits the release of glucagon, a hormone that increases blood sugar by stimulating the liver to release glucose

Nausea, diarrhea, vomiting, and constipation commonly occur within the first month of starting.[ref][ref] Note that for many people, gastrointestinal side effects seem to be dose-related

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For weight management, specific signs include insufficient weight loss despite continued medication adherence and lifestyle efforts, or failure to achieve clinically meaningful weight reduction within the expected timeframe