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PubMed Central, doi:10.5665/sleep.4006
These work locally by drawing water into the rectum and lubricating stool
A peptide that makes a half-eaten plate feel like enough is solving a problem willpower rarely beats
A Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) enrolled 338 adults with obesity and reported mean body weight reductions of up to approximately 24% over 48 weeks at the highest dose studied (12 mg weekly)
Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study
