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It is the second most common optic neuropathy and often results in permanent blindness in one or both eyes

While this leads to more consistent appetite suppression, it can result in prolonged, low-grade constipation or mild nausea that takes several weeks to fully resolve as the body adapts

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It can affect multiple organ systems, including respiratory, cardiovascular, neurological, musculoskeletal and immunological, with the constellation of more than 200 possible symptoms varying from person to person and commonly including debilitating fatigue

Chen S, Zhu Y, Liu Z, Gao Z, Li B, Zhang D, Zhang Z, Jiang X, Liu Z, Meng L, Yang Y, Shi B (2015) Grape seed proanthocyanidin extract ameliorates diabetic bladder dysfunction via the activation of the Nrf2 pathway