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A 2025 systematic review and meta-analysis published in Obesity Reviews evaluated changes in body weight, BMI, and waist circumference following GLP-1 RA discontinuation

These include the gut-derived hormones, such as the potent incretins glucagon-like polypeptide-1 (GLP-1) and gastric inhibitory peptide (GIP) and the -cell hormone amylin

Compared to the original peptide, which is rapidly degraded by enzyme dipeptidyl peptidase-4 (DPP-4) in 1.5 min [21], GLP-1 RAs show a long-term action in resisting the degradation through DPP-4