glp-1 in the brain Mechanisms of Modulating Craving and Addiction: Neurobiological and Translational Insights JCI - Glucagon-like peptide-1 receptors

I think this is an overblown concern

[DOI] [PubMed] [Google Scholar] 141.Finan B, Clemmensen C, Zhu Z, et al

The most commonly reported adverse events are gastrointestinal reactions, including nausea, vomiting, diarrhea, and constipation, which typically occur during the early phase of treatment and tend to diminish or resolve with continued therapy ( With regard to the unique clinical context of OSAS, no evidence currently suggests that tirzepatide exacerbates sleep apnea symptoms or induces severe hypoxemic events ( Despite its overall favorable safety profile, certain adverse reaction risks warrant attention

Of the participants, 50.9 percent were male, and the average age was 70.8 years

If the FDA will require outcomes trials for future approvals in obesity, this will add considerable time and cost to drug development