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Pharmacokinetics (How Long They Last): Semaglutide: Half-life: Approximately 7 days Reaches steady state: After 4-5 weeks Duration of action: Remains active for one week between doses Time to peak concentration: 1-3 days after injection Tirzepatide: Half-life: Approximately 5 days Reaches steady state: After 4 weeks Duration of action: Remains active for one week between doses Time to peak concentration: 8-72 hours after injection Both medications are designed for once-weekly dosing and maintain therapeutic levels throughout the week

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RM was the clinical trial lead in coordinating all activities in the conduct of the study

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In 2022, global pooled analyses estimated that approximately one in eight individuals worldwide were living with obesity, encompassing 890 million adults and 160 million children and adolescents [2]