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Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe(/) mice

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65 Early investigations revealed that SSc patients exhibited higher levels of CD4+ DPP4+ T cells in their peripheral blood, and DPP4 activity in T cells was associated with disease severity

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The primary endpoint occurred in 569 of 8803 participants (6.5%) in the semaglutide group compared with 701 of 8801 participants (8.0%) in the placebo group, corresponding to an HR of 0.80 (95% CI, 0.720.90