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Risk of bias: all four RCTs were rated low risk by RoB2 (with some concerns for open-label outcome ascertainment in three trials, a domain-specific issue that does not alter the overall RoB2 category from low)

Benefits, risks, and doctor-guided strategies explained.

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Unlike traditional alcohol dependence medications, which often work by creating aversion or blocking euphoria after drinking, GLP-1 therapy works upstream reducing the desire before it takes hold

The company plans more than 20 anti-obesity trials, including 10 Phase 3 studies targeted for 2026, as it builds out its obesity franchise
