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Risks of fatal opioid overdose during the first year following nonfatal overdose
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doi: 10.1016/S2213-8587(18)30303-6
Wharton, the STEP 5 Study Group, Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial
Under the action of unhealthy metabolic factors (obesity, diabetes), ER stress is initiated, and IRE-1 is activated, which in turn leads to the phosphorylation of IRS1 at the serine 307 residue by activating JNK, thereby impairing insulin signaling
