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Recent studies have revealed that neuronal Glp1r activation in mice is required for the reduction in systemic inflammation through a unique set of neurotransmitter systems 32 and that brainstem neurons can sense peripheral cytokines and exert control over systemic immune responses 33 , suggesting complex neuro-immune communication circuits
The potential for improving cardio-renal outcomes by sodium-glucose co-transporter-2 inhibition in people with chronic kidney disease: a rationale for the EMPA-KIDNEY study
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