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In addition to the overexpression of inflammatory cytokines such as IL-1, IL-6, and TNF- in the adipose tissue, an increase in DPP-4 enzyme and a decrease in the GLP-1 level has been observed in obese diabetic individuals with insulin resistance [61,62]
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[DOI] [PMC free article] [PubMed] [Google Scholar] Knepel W, Chafitz J, Habener JF
Tirzepatide works by activating receptors for glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) hormones
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