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Research shows that people with obesity often have lower GLP-1 responses to food, which can make appetite control harder
J., Capehorn, M., Charpentier, G., Dotta, F., Henkel, E., Lingvay, I., Holst, A

These effects are typically dose-dependent, most prominent during dose escalation, and tend to diminish over time

Pre-diabetes: For those at risk of developing diabetes, Semaglutide can help in delaying or preventing the onset of the disease

It is considered an uncommon but well-documented reaction that is almost always mild to moderate
