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Weight Loss and Cardiovascular Outcomes Although semaglutide led to an average placebo-adjusted weight loss of 8.5% (Semaglutide arm lost 8.5% more body weight than those who took the placebo), its cardiovascular risk reduction was not linked to how much weight patients lost

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For adults over 40, the maintenance phase is not a passive thing it requires conscious decisions about whether to stay on a maintenance dose, taper down, or come off entirely

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5 Incretin hormones are released from the gut in response to nutrient consumption, and they cause insulin release in a glucose-dependent manner