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During titration, it is not recommended to increase by more than 2.5 mg every 4 weeks to avoid side effects

This typically resolves as the body adapts

Many patients begin to notice a drop in their appetite within the very first few weeks

The distinction matters because rosacea management involves vasodilatory triggers (heat, alcohol, spice) and topical agents like metronidazole or azelaic acid that do overlap with perioral dermatitis treatment, but the underlying condition and long-term management are different
