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In the current review, we discussed the dysregulation of IGF-1/GLP-1 signaling in neurodegenerative manifestations of ALS like a genetic anomaly, oligodendrocyte degradation, demyelination, glial overactivation, immune deregulation, and neuroexcitation

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Semaglutide doses typically start low and increase gradually over weeks to reach therapeutic levels that support sustainable weight loss

Relative risk (RR) values were significant for hospitalization due to heart failure (HF) 0.24 95% CI 0.120.57 (n=2

1 reducing the dosage for an additional 1-2 weeks before considering an increase again
