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Rather than competing with peptide ligands for the orthosteric binding site, these molecules bound to an allosteric pocket within the transmembrane domain of the receptor

Graphic abstract Similar content being viewed by others Introduction Depression is a chronic and recurrent mood disorder and one of the major health concerns in modern society, which, according to the World Health Organization (WHO), affects more than 264 million people worldwide

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However, addressing the underlying emotional issues that drive emotional eating typically requires psychological work alongside medication