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For Phase 1, that is 0.25mg

Use of continuous glucose monitoring in diagnosis and management of cystic fibrosis-related diabetes in children

6 , e009417 (2016)

Be aware that transdermal berberine bioavailability is less established than oral supplementation

Patients taking medications that promote weight gain (such as insulin, sulfonylureas, or certain antipsychotics) may experience attenuated weight loss, though glucose control typically improves regardless
