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GutBrain Axis and Vagal Modulation of Craving The gutbrain axis serves as a bidirectional communication system between the gastrointestinal tract and CNS, playing a crucial role in energy homeostasis, reward processing, and motivational states
The "canary in the coal mine" metaphor lands hardweight trajectory as early warning system for multisystem decline, not just a nutritional footnote

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Li JR, Cao J, Wei J, Geng W

Zepbound: The FDA-approved form of tirzepatide for weight loss is called Zepbound
