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As patients lose substantial weight, their metabolic demands change, potentially altering the dose of levothyroxine needed to maintain euthyroid status

doi:10.1016/j.jchf.2020.09.005 Grant C, Richards JB, Frakes M, Cohen J, Wilcox SR

Diabetes, Obesity and Metabolism, 22 (9), 1772-1780

Genetic variations in GLP-1 receptor (GLP1R), GIP receptor (GIPR), and appetite-regulation genes (FTO, MC4R) can predispose individuals to greater weight gain and reduced satiety signals

Anyone can sell you a vial online, but that approach is risky and incomplete
